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　　Dr. Zhu received his Ph.D. degree in Department of Biotechnology of Wuhan University, China, and then went to work in Prof. Jan Tytgat’s Laboratory of Toxicology, Leuven University, Belgium, as a postdoctoral fellow. He came back to China in 2004. He is the principle investigator of the Group of Peptide Biology and Evolution, and a peptide expert who enjoys the special subsidy of the State Council. Dr. Zhu is a recipient of several major research funds in China. He has published more than 60 peer-reviewed scientific papers in Nat Commun, MBE, Proc Natl Acad Sci USA, Mol Cell Proteomics, FASEB J, Trends Microbiol, Cell Mol Life Sci, etc. ....
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Publications more >>
  • Gao B, Zhu S* (2024) The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization. Cell Mol Life Sci 81:230.
  • Gao B, Li P, Zhu S* (2024) Single deletion unmasks hidden anti-Gram-negative bacterial activity of an insect defensin-derived peptide. J Med Chem 67:2512–2528.
  • Gao B, Zhu S* (2023) Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins. Front Microbiol 14:1195156.
  • Gao B, Zhu S* (2023) Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses. Front Microbiol 14:1118025.
  • Gu J, Isozumi N, Gao B, Ohki S, Zhu S* (2022) Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering. Front Microbiol 13:1053078.
  • Qi S, Gao B, Zhu S* (2022) A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability. J Fungi 8:174.
  • Zhu S*, Gao B, Umetsu Y, Peigneur S, Li P, Ohki S, Tytgat J (2022) Adaptively evolved human oral actinomyces-sourced defensins showtherapeutic potential. EMBO Mol Med 14:e14499.
  • Gu J, Isozumi N, Yuan S, Jin L, Gao B, Ohki S, Zhu S* (2021) Evolution-based protein engineering for antifungal peptide improvement. Mol Biol Evol 38: 5175–5189.
  • Gao B, Zhu S* (2021) A fungal defensin targets the SARS-CoV-2 spike receptor-binding domain. J Fungi 7:553.
  • Qi S, Gao B, Zhu S* (2021) Molecular diversity and evolution of antimicrobial peptides inMusca domestica. Diversity 13:107.
  • Zhu L, Gao Bζ, Yuan Sζ, Zhu S* (2019) Scorpion toxins: positive selection at a distal site modulates functional evolution at a bioactive site. Mol Biol Evol 36: 365-375. (ζ These authors contributed equally to this work)
  • Zhou W, Gao B, Zhu S* (2018) Did cis- and trans-defensins derive from a common ancestor？ Immunogenetics 71: 61-69.
  • Ji X, Zhang S, Gao B, Zhu S* (2018) Receptor variability-driven evolution of snake toxins. Zool Res 39: 431-436.
  • Zhao Jζ, Yuan Sζ, Gao B, Zhu S* (2018) Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion. FEMS Microbiol Lett 365(15). (ζ These authors contributed equally to this work)
  • Gu J, Gao B, Zhu S* (2018) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution. Dev Comp Immunol 87: 90-97.
  • Gao B, Dalziel J,Tanzi S and Zhu S* (2018) Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins. Amino Acids 50:1025-1043.
  • Zhang S, Gao B, Wang X and Zhu S* (2018) Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin.Toxins 10:227.
  • Gao B, and Zhu S* (2018) Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. Front Microbiol 9:320.
  • Yuan S, Gao B, and Zhu S* (2017) Molecular dynamics simulation reveals specific interaction sites between scorpion toxins and Kv1.2 channel: implications for design of highly selective drugs. Toxins 9:354.
  • Wang X, Gao B, Zhu S* (2016) Exon shuffling and origin of scorpion venom biodiversity. Toxins (Basel) 9:pii:E10.
  • Wu Y, Gao B, Zhu S* (2017) New fungal defensin-like peptides provide evidence for fold change of proteins in evolution. Biosci Rep 37:pii: BSR20160438.
  • Zhu S*, Gao B (2017) Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or Endogenous Receptors? Heredity (Edinb). 118:453-465.
  • Zhang Sζ, Zhu Lζ , Yu J, Xu J, Gao B, Zhou C, Zhu S* (2016) Evaluating the potential of a loop-extended scorpion toxin-like peptide as a protein scaffold. Protein Eng Des Sel 29:607-616. (ζ These authors contributed equally to this work)
  • Gao B, Zhu S* (2016) The drosomycin multigene family: three-disulfide variants from Drosophila takahashii possess antibacterial activity. Sci Rep 6:32175.
  • Wu J, Gao B, Zhu S* (2016) Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. FASEB J 30, 2602–2614.
  • Zhu L, Peigneur S, Gao B, Zhang S, Tytgat J, Zhu S* (2016) Target-driven positive selection at hot spots of scorpion toxins uncovers their potential in design of insecticides. Mol Biol Evol 33:1907–1920.
  • Zhang S, Gao B, Zhu S* (2015) Independent origins of scorpion toxins affecting potassium and sodium channels. Evolution of Venomous Animals and Their Toxins. DOI 10.1007/978-94-007-6727-0_12-1. Springer Science+Business Media Dordrecht.
  • Wang X, Umetsu Y, Gao B, Ohki S, Zhu S* (2015) Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter. Biochem Pharmacol 93:232-239.
  • Zhu S*, Peigneur S, Gao B,Umetsu Y, Ohki S, Jan Tytgat (2014) Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function. Mol Biol Evol 31:546-559.
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