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  • Introduction
  • Faculty and staff
  • Students and postdoctoral fellows
  • Selected publications
  • Principal Investigator
  • Location: Home>Research>Research Divisions>Group of Molecular Toxicology>Selected publications
    Selected publications
    1. Chen LP, Wang P, Sun YJ, Wu YJ. Direct interaction of avermectin to EGFR mediates the penetration resistance in Drosophila larvae. Open Biol. 2016, (in press).
    2. Long DX, Wang P, Sun YJ, Chen R, Wu YJ. Neuropathy target esterase is degraded by the ubiquitin-proteasome pathway with ARA54 as the ubiquitin ligase. Biochemistry. 2015, 54(50):7385-7392.
    3. Wang P, Wang Q, Yang L, Qin QL, Wu YJ. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Life Sci. 2015, 131: 57-62.
    4. Xu MY, Wang P, Sun YJ, Wang HP, Liang YJ, Zhu L, Wu YJ. Redox status in liver of rats following subchronic exposure to the combination of low dose dichlorvos and deltamethrin. Pestic Biochem Physiol. 2015, 124: 60-65.
    5. Xu MY, Sun YJ, Wang P, Xu HY, Chen LP, Zhu L, Wu YJ. Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2015, 28 (6):1216-1223.
    6. Wang P, Wu YJ. Applications of metabonomics to pesticide toxicology. Curr Drug Metab. 2015, 16(3): 191-199.
    7. Wang HP, Liang YJ, Sun YJ, Hou WY, Chen JX, Long DX, Xu MY, Wu YJ. Subchronic neurotoxicity of chlorpyrifos, carbaryl and their combination in rats. Environ Toxicol. 2014, 29: 1193-1200.
    8. Long DX, Hu D, Wang P, Wu YJ. Tri-ortho-cresyl phosphate induces autophagic cell death in human neuroblastoma SH-SY5Y cells. Mol Cell Biochem 2014, 396:33-40.
    9. Wang P, Wang HP, Xu MY, Liang YJ, Sun YJ, Yang L, Li L, Li W, Wu YJ. Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study. Food Chem Toxicol 2014, 70:222-230.
    10. Chen JX, Wu YJ. CREB is required for cAMP/PKA signals up-regulating neuropathy target esterase expression. DNA Cell Biol. 2013, 32:199-205.
    11. Wang HP, Liang YJ, Sun YJ, Chen JX, Hou WY, Long DX, Wu YJ. 1H NMR-based metabonomic analysis of the serum and and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides. Chem-Biol Interact. 2013, 203:588-596.
    12. Luo L, Sun YJ, Yang L, Huang S, Wu YJ. Abamectin induces P-glycoprotein expression in S2 cells via calcium/calmodulin/NF-κB pathway. Chem-Biol Interact. 2013, 203:430-439.
    13. Chen JX, Sun YJ, Wang P, Long DX, Li W, Li L, Wu YJ. Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology. 2013, 310:92-97.
    14. Chang PA, Sun YJ, Huang FF, Qin WZ, Chen YY, Zeng X, Wu YJ. Identification of human patatin-like phospholipase domaincontaining protein 1 and a mutant in human cervical cancer HeLa cells. Mol Biol Rep. 2013, 40:5597-5605.
    15. Luo L, Sun YJ, Wu YJ. Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways. Insect Biochem Mol Biol. 2013, 43:627-634.
    16. Zhu L, Wang P, Qin QL, Zhang H, Wu YJ. Protective effect of polypeptide from larva of housefly (Musca domestica) on hydrogen peroxide-induced oxidative damage in HepG2 cells. Food Chem Toxicol. 2013, 60:385-390.
    17. Liang YJ, Wang HP, Long DX, Li W, Wu YJ. A metabonomic investigation of the effects of 60 days exposure of rats to two types of pyrethroid insecticides Chem-Biol Interact. 2013, 206:302-308.
    18. Sun YJ, Wang HP, Liang YJ, Yang L, Li W, Wu YJ. An NMR-based metabonomic investigation of the subacute effects of melamine in rats. J Proteome Res. 2012, 11: 2544-2550.
    19. Liang YJ, Wang HP, Long DX, Wu YJ. Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats. Bioanalysis. 2012, 4(24):2897-2907
    20. Wang HP, Liang YJ, Zhang Q, Long DX, Li W, Li L, Yang L, Yang XZ, Wu YJ. Changes in metabolic profiles of urine from rats following chronic exposure to anticholinesterase pesticides. Pestic Biochem Physiol. 2011, 10: 232-239.
    21. Wang Q, Wu YJ. Lysophosphatidylcholine induces Ca2+ mobilization in Jurkat human T lymphocytes and CTLL-2 mouse T lymphocytes by different pathways. Eur J Pharm Sci. 2011, 44: 602-609.
    22. Chen JX, Long DX, Hou WY, Li W, Wu YJ. Regulation of neuropathy target esterase by the cAMP/protein kinase A signal. Pharmacol Res. 2010,62: 259-264.
    23. Sun YJ, Long DX, Li W, Hou WY, Wu YJ, Shen JZ. Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells. Toxicol Lett. 2010, 192: 206-211.
    24. Chang PA, Wu YJ. Neuropathy target esterase: An essential enzyme for neural development and axonal maintenance, Int J Biocehm Cell Biol. 2010, 42:573-575.
    25. Long DX, Chang PA, Liang YJ, Yang L, Wu YJ. Degradation of neuropathy target esterase by macroautophagic lysosomal pathway. Life Sci. 2009, 84:89-96.
    26. Li Q, Wu YJ. A fluorescent, genetically engineered micro-organism that degrades organophosphates and commits suicide when required. Appl Microbiol Biotechnol. 2009, 82:749-756.
    27. Liu CY, Chang PA, Wu YJ. Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? Chem-Biol Interact. 2009, 181:37-44.
    28. Chang PA, Wu YJ. Motor neuron diseases and neurotoxic substances: A possible link? Chem-Biol Interact. 2009, 180:127-130.
    29. Hou WY, Long DX, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate. Toxicol Sci. 2009, 109:276-285.
    30. Long DX, Wu YJ. Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate. Toxicol Lett. 2008, 181:47-52.
    31. Hou WY, Long DX, Wang HP, Wang Q, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate induced delayed neurotoxicity in hens. Toxicology. 2008, 252:56-63.
    32. Chen R, Chang PA, Ding-Xin Long, Yang L, Wu YJ. Down-regulation of neuropathy target esterase by protein kinase C activation with PMA stimulation. Mol Cell Biochem. 2007, 302:179-185.
    33. Yang L, Liu J, Wu YJ, Li W, Gao XW, Leng XF. Oral administrations of methamidophos and TOCP have different effects on in vitro protein phosphorylation levels from subcellular fractions of hen brain. Pestic Biochem Physiol. 2007, 88:20-25.
    34. Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80:886-892.
    35. Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.
    36. Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environ Toxicol Pharmacol. 2007, 24:67-71.
    37. Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2007, 424:22-26.
    38. Chang PA, Long DX, Wu YJ. Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicol Lett. 2007, 174: 42-48.
    39. Chang PA, Long DX, Wu YJ. Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase Mol Cell Biochem. 2007, 306:25-32
    40. Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159: 65-72.
    41. Chang PA, Wu YJ. Effect of tri-o-cresyl phosphate on cytoskeleton in human neuroblastoma SK-N-SH cell. Mol Cell Biochem. 2006, 290: 145-151.
    42. Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39: 429-440.
    43. Chang PA, Wu YJ, Chen R, Li M, Li W, Qin QL. Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line. Mol Cell Biochem. 2005, 272: 47-54.
    44. Chang PA, Chen R, Wu YJ. Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line. Mol Brain Res. 2005, 151: 30-38.
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